Joseph Merrick Myth | The Elephant Man

In 1980, David Lynch's work of art The Elephant Man was launched. The film told the tale of John Merrick, a disastrously deformed yet wonderful and brilliant Englishman. The way it hit the displays in 1980, it grew to become a cult hit with victims of neurofibromatosis, the illness that the Elephant Man was considered to have had. Earlier, it was though actually that he suffered with elephantiasis, an exotic disease causes by organisms in the bloodstream. Nevertheless, it was recommended in 1979 that Merrick got Proteus symptoms or what we called now "Elephant Man's Disease", that causes abnormal, unchecked development of bones, skin area, and other body systems. Less than 90 cases of Proteus are actually recorded, while NF happens in 1 in every 5,000 births. No illness has ever made a degree of deformity comparative to Merrick's.
Joseph Carey Merrick was given birth in Leicester of England in 1862. He started growing physically disfiguring tumors before age 2 and his problem rapidly worsened, making one of his 2 arms entirely useless. Nonetheless, he was identified as a wonderfully innovative and brilliant boy. When Joseph was ELEVEN, his mom, Mary Jane, who had been also actually handicapped, passed away, and Joseph's dad married another one. Joseph's stepmother wasn't nearly even as compassionate as his mom, and the woman even presented Joseph's dad a choice: "Joseph, or me." Joseph was escaped from his home and traveled to live at the Leicester Association Workhouse, and sold boot polish on the block. Nevertheless, he was continuously taunted by crowds of people of cruel children and quickly moved to live on another line of job.

Joseph's tried to find standard work were not successful. Ill with bronchitis, and needing surgery because of the intrusion of growths into his tonsils, Joseph would more than likely have died on the roads of Leicester, if it were not for a compassionate showman called Tom Norman. Norman has been the UK's answer to P.T. Barnum, actually got his nick name, "The Silver King", and that was from the famous American impresario due to the fancy silver jewelry he dressed in. Finding himself away from alternatives and eager for medical health care, Merrick pitched him self to Sam Torr, one more showman, who consequently introduced him to Norman. he paid out for the surgeries Merrick needed and aided Merrick come to be an effective museum freak. Beneath Norman's tutelage, Joseph accumulated 2 HUNDRED pounds, a huge sum of cash at the time. Nevertheless, while visiting Belgium, Joseph became divided from his guardian. Unsuspecting and quite sickly, he was a great target for thieves, and an unethical Austrian showman stole his small fortune.

Coming back home from Belgium, Joseph was found out in a train station in Liverpool by Dr. Frederick Treves, and he had formerly seen Merrick on show in a medical university. Merrick was struggling with bronchitis and weakness, and Treves transferred him back to the White chapel Hospital. This hospital had become Merrick's permanent residence; in his living room he wrote poems and prose then he built models through card stock, his most well-known being of the St. Philip's tall in Birmingham, which generally Merrick hadn't seen before but manufactured from studying architectural paintings. While being in the hospital, nevertheless, Merrick has become a freak of a various sort. Treves showed him just before classes of medical college students, where he stood nude before leering throngs and was subjected to embarrassing examinations. It became trendy among people of London's high class to see the Elephant Man and even mask their outrage as the conversed with the smart and well-spoken man. His guests brought him all kinds of presents, like a beautiful shaving set, which certainly Merrick wasn't able to use because of the problem of his pores and skin. He struck up a pen-pal partnership with a popular actress of the day, who gave a promise she would got back to see him again, even though she never did.

Since Merrick became more relaxing with other individuals, he was taken on trips and even visited a cinema. He shook hands together with people and spoke to people, even ladies, with ease. Regrettably, his unprecedented sense of self esteem appeared too late, and he passed away while he was sleep in April 11, 1890. Gossips spread that Merrick "the Elephant Man" had been killed, but Dr. Treves actually dispelled these rumors, exposing the true reason of Merrick's dying to be asphyxiation. He also had used to sleep lying down, just like a "normal person", but the weight of his tumors on the head and neck had smashed his trachea.

Sian Mumtaz | The Giant Head Diseas | ELEPHANT MAN DISEASE

Do giantmen exist? Well, a peculiar disease could make your mind GIGANTIC! Proteus symptoms transforms a guy into a monster and there is nothing anyone or even experts can do to help him. The terrible disease affects the bone structure of patient’s head, hands and feet causing to make them grow in uncontrollabe way!

Let’s check out the shocking case of the person with the huge head, and some more cases of the Elephant Man Disease.

Sian Mumtaz is one of them, the Pakistani Elephant Man who's fighting social damnation because of his gruesome exterior look. Because of this ruthless disease referred to as the Proteus symptoms, the bone fragments in his head, feet as well as arms are continuously increasing turning him for a monster lookalike. The TWENTY TWO year old man is considered to have problems with a difference that the well known Elephant Man, Joesph Merrick had. The condition appears to be affecting his bone structure proportionally.

Sian Mumtaz comes from the outskirts of Lahore, and in spite of his monstrous appearance, he’s a mild giant and he’s been recognized and comforted by the city he lives in. In fact, the support he got from his friends helped him overcome the fact that his terrible disease is truly a wicked curse presented upon him by way of a vengeful God.

If Sain does really have problems with Proteus Syndrome, nothing else can be carried out to help him, except some operations to eliminate the surplus skin, nonetheless it is only going to grow back in anytime.

But what's Proteus Syndrome and may It Be Cured?

Proteus syndrome is really a genetic disease which mostly causes a person’s skin to grow fast and the bones to build up atypically, often associated with tumors on half your body.

How could it be cured?

Unfortunately, there is absolutely no cure till now! The head disease does not have any known cure since it is incredibly rare. There were tests completed using one person, a team of experts tested Rapamycin on a patient presumably experiencing Proteus Syndrome, plus they discovered it to work really good, however the patient’s analysis of the Elephant Man Disease has been extremely contested by others.

In a recently available interview, the type, abominable looking giant reported that:









Discover more photos and a video clip of The Pakistani Elephant Man Sian Mumtaz below:

Sarah Atwell tells her suffering from "Elephant Man Disease"

It's "Elephant Man disease". One of the very rare diseases which occur to a person within a million people , when we back to history , we find that a very small number of people diagnosed with this deadly disease . The first person who suffered from this disease was Joseph Merrick , that was at the end of the nineteenth century , now , at this time, the disease came back again and that a girl called "Sarah Atwell" has been injured with the same disease "Elephant Man Disease", so doctors re memorized that disease and how could they cure it again.

"Elephant Man disease" is a swelling of neurofibromatosis , and its symptoms was the same symptoms that appeared on the " Sarah " when she was hit by the disease . But the symptoms of the disease that appeared on Sarah were less severe than the symptoms that hit Joseph in the past. The symptoms appeared clearly on her face and some parts of her body . Sarah yielded to an intense therapeutic examination to diagnose the disease accurately , and a big staff of doctors and specialists studied Sarah's case carefully. We note also that a documentary film made about the disease when it infected Joseph of several years ago. The purpose of the film was to display the mental and health state of Joseph when he was hit by the disease.

"Elephant Man disease" is a hereditary strike that create a neuromas Levy , and this disturbs the growth of cells in the nervous system and this leads to create tumors in different places in the body.

Sarah tells the her story , she says she was in the third grade when she was hit by the disease , her friends called here with a bad names like " the ugly " and " the fat face " and this affected on her psychological state a lot and Sarah was crying so much because of the cynicism she exposed to. Sarah says she thought that the disease will stay for a short period , this is what the doctors told her, but it stayed for a long time . Sarah undergone for eight surgeries , but this was not a big problem , the big problem was the bullying that she has exposed to in school from her friends , because they thought that the disease is contagious so her friends shunned her a lot.

In 2010, Sarah undergo-ned for three surgeries in her face to remove the tumor , doctors did it , and they really succeeded in removing it, but the problem they said was that they were not sure whether the disease may come back again or not. Sarah's health state was much improved , she said that she is ready now to plan for the future , and hopes to succeed in it , she exposed to really big problems , and she was able to pass them successfully.

Sarah has already succeeded in overcoming this disaster disease, and doctors and specialists have succeeded in treating Sarah , this is considered as a brilliant medical success. But, the question remains: Is it possible to see diagnosed people with this disease again? Can we see the " Elephant Man disease " again?

Elephant Man Disease | Gene May Explain 'Elephant Man' Disorder

Making use of new DNA sequencing methods, experts have tracked along the gene defect underlying an uncommon disease known as Proteus syndrome that triggers bone plus skin tissue to develop to occasionally grotesque amounts. The change may clarify the affliction for the Elephant Man, a distorted Englishman whose terrible life within the late 1800s happens to be depicted on stage and also film.

Proteus syndrome, called when it comes to shape-shifting of Greek sea god, is believed to affect just a few hundred people. Skin along with other cells grow abnormally, resulting in enlarged hands, feet, and tumors that may cause pain along with other problems and quite often require amputation. Considering that the disease does not run in families, and just some areas of the body are affected, German skin specialist Rudolf Happle-hypothesized in 1987 that rather than caused by an inherited change that permeates all of the cells of an innovative new embryo, it may be as a result of a spontaneous change that appears in a single cell at the beginning of development. The generating person would then be a mixture of normal tissue and ones with all the mutation.

However confirming that "mosaic" theory has not been easy as geneticists would never follow their common strategy of following the gene by examining families for which some members come into the condition as well as others do not, says Leslie Biesecker, chief for the National Human Genome Research Institute's hereditary Diseases study Branch in Bethesda, Maryland, that has studied Greek deity patients for 16 years.

So nowadays, Biesecker's staff turned to a technique for which scientists use next generation DNA to sequencing to affordably decode all of the genome's protein coding DNA, referred to as "exome." They sequenced the exomes of irregular and normal cells from 7 Proteus patients' body parts to compared all of them with healthy individuals exomes to ferret out of the culprit gene.

All of the Proteus patients discussed exactly the same single-base mutant in a gene named AKT1. Exactly the same glitch starred in 26 of 29 patients identified as having Proteus disease as well as in 1% to about 50% for the DNA in good cell samples, the scientists report online nowadays within the New England log of Medicine (NEJM). To reinforce the situation that the change was causing illness, the researchers also revealed that the AKT required protein is overactive within the abnormal tissues. The AKT1 G., that is piece of a cell-growth path, has additionally been discovered to be mutated in a few cancers.

Though exome sequencing has been utilized to get the genes for a large number of rare diseases in past times a couple of years, this is actually the first "mosaic" illness to be cracked with all the technique, tells healthcare geneticist Dian Donnai for the University of Manchester, U.K. The job should act as a model for researching different mosaic genetic conditions.

The discovery might also want to help medical doctors diagnose thought Proteus cases and maybe result in treatments. Companies already are developing cancer medications that focus on the AKT path, and another that obstructs patients' mutated as a type of AKT might end or slow down the disease's evolution, Biesecker recommend|evolutions. Patients' family members are "realistic" about how precisely long clinical studies take, but "we cannot help being thrilled," says Tracey Whitewood-Neal, head for the Proteus Syndrome basic foundation UK in East Sussex, whose sixteen yr old son, Jordan, took part in the research.